D1 Dopamine Receptor Coupling to PLCβ Regulates Forward Locomotion in Mice
Identifieur interne : 000E15 ( Main/Exploration ); précédent : 000E14; suivant : 000E16D1 Dopamine Receptor Coupling to PLCβ Regulates Forward Locomotion in Mice
Auteurs : Ivan O. Medvedev [États-Unis] ; Amy J. Ramsey [Canada] ; Shababa T. Masoud [Canada] ; Marie Kristel Bermejo [Canada] ; Nikhil Urs [États-Unis] ; Tatyana D. Sotnikova [Italie] ; Jean-Martin Beaulieu [Canada] ; Raul R. Gainetdinov [Italie, Russie] ; Ali Salahpour [Canada]Source :
- The Journal of Neuroscience [ 0270-6474 ] ; 2013.
Abstract
Several studies have reported the coupling of dopamine signaling to phospholipase C β (PLCβ) both
Url:
DOI: 10.1523/JNEUROSCI.2382-13.2013
PubMed: 24227722
PubMed Central: 3828465
Affiliations:
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Dopamine Receptor Coupling to PLCβ Regulates Forward Locomotion in Mice</title>
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Dopamine Receptor Coupling to PLCβ Regulates Forward Locomotion in Mice</title>
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<author><name sortKey="Beaulieu, Jean Martin" sort="Beaulieu, Jean Martin" uniqKey="Beaulieu J" first="Jean-Martin" last="Beaulieu">Jean-Martin Beaulieu</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Psychiatry and Neuroscience, Faculty of Medicine, Laval University and Institut Universitaire en Santé Mentale de Québec, Québec City, Québec G1J 2G3, Canada</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p>Several studies have reported the coupling of dopamine signaling to phospholipase C β (PLCβ) both <italic>in vitro</italic>
and <italic>in vivo</italic>
. However, the precise physiological relevance of this signaling pathway in mediating dopamine behaviors is still unclear. Here we report that stimulation of dopamine receptor signaling <italic>in vivo</italic>
with systemic administration of apomorphine, amphetamine, and cocaine leads to increased production of inositol triphosphate (IP<sub>3</sub>
) in the mouse striatum. Using selective antagonists and dopamine D<sub>1</sub>
and D<sub>2</sub>
receptor knock-out animals, we show that the production of IP<sub>3</sub>
is mediated by the D<sub>1</sub>
receptor, but not the D<sub>2</sub>
receptor. A selective blocker of PLCβ, U73122, was used to assess the physiological relevance of D<sub>1</sub>
-mediated IP<sub>3</sub>
production. We show that U73122 inhibits the locomotor-stimulating effects of apomorphine, amphetamine, cocaine, and SKF81297. Furthermore, U73122 also suppresses the spontaneous hyperactivity exhibited by dopamine transporter knock-out mice. Importantly, the effects of U73122 are selective to dopamine-mediated hyperactivity, as this compound does not affect hyperactivity induced by the glutamate NMDA receptor antagonist MK801. Finally, we present evidence showing that an imbalance of D<sub>1</sub>
- and D<sub>2</sub>
-mediated signaling following U73122 treatment modifies the locomotor output of animals from horizontal locomotor activity to vertical activity, further highlighting the importance of the PLCβ pathway in the regulation of forward locomotion via dopamine receptors.</p>
</div>
</front>
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<li>États-Unis</li>
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<li>Ontario</li>
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</settlement>
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<name sortKey="Urs, Nikhil" sort="Urs, Nikhil" uniqKey="Urs N" first="Nikhil" last="Urs">Nikhil Urs</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Ramsey, Amy J" sort="Ramsey, Amy J" uniqKey="Ramsey A" first="Amy J." last="Ramsey">Amy J. Ramsey</name>
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<name sortKey="Beaulieu, Jean Martin" sort="Beaulieu, Jean Martin" uniqKey="Beaulieu J" first="Jean-Martin" last="Beaulieu">Jean-Martin Beaulieu</name>
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<name sortKey="Salahpour, Ali" sort="Salahpour, Ali" uniqKey="Salahpour A" first="Ali" last="Salahpour">Ali Salahpour</name>
</country>
<country name="Italie"><noRegion><name sortKey="Sotnikova, Tatyana D" sort="Sotnikova, Tatyana D" uniqKey="Sotnikova T" first="Tatyana D." last="Sotnikova">Tatyana D. Sotnikova</name>
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<name sortKey="Gainetdinov, Raul R" sort="Gainetdinov, Raul R" uniqKey="Gainetdinov R" first="Raul R." last="Gainetdinov">Raul R. Gainetdinov</name>
</country>
<country name="Russie"><noRegion><name sortKey="Gainetdinov, Raul R" sort="Gainetdinov, Raul R" uniqKey="Gainetdinov R" first="Raul R." last="Gainetdinov">Raul R. Gainetdinov</name>
</noRegion>
<name sortKey="Gainetdinov, Raul R" sort="Gainetdinov, Raul R" uniqKey="Gainetdinov R" first="Raul R." last="Gainetdinov">Raul R. Gainetdinov</name>
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